a Record control number 000322483500029

a ISSN 1355-008X

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WK100

b Item number .E34 2013

a Personal name Inancli, Serap Soytac

h Medium Electronic Document

a Title Effect of cabergoline on insulin sensitivity, inflammation, and carotid intima media thickness in patients with prolactinoma

c Statement of responsibility, etc Serap Soytac Inancli, Alper Usluogullari, Yusuf Ustu, Sedat Caner, Abbas Ali Tam, Reyhan Ersoy, Bekir Cakir.

b Name of publisher, distributor, etc Humana Press Inc,

c Date of publication, distribution, etc 2013.

a Summary, etc The aim of this study was to evaluate the effect of Cabergoline on insulin sensitivity, inflammatory markers, and carotid intima media thickness in prolactinoma patients. Twenty-one female, newly diagnosed patients with prolactinoma were included in the study. None of the patients were treated previously. Cabergoline was given as treatment, starting with 0.5 mg/day and tapered necessarily. Blood samples were taken for prolactin, highly sensitive C-reactive protein, homocysteine, total cholesterol, low density lipoprotein (LDL) cholesterol, fasting glucose, insulin, and HOMA (homeostasis model assessment of insulin resistance) score was calculated, prior to and 6 months after starting treatment. The body mass index (BMI) was measured and carotid intima media thickness (CIMT) was evaluated for each patient prior to and 6 months after the treatment. The prolactin levels and LDL decreased significantly after cabergoline treatment. Insulin sensitivity improved independently from the decrease in prolactin levels and BMI. The significant decrease in homocysteine and hs-CRP was not related with the decrease in prolactin levels. The significant decrease in CIMT was independent from the decrease in prolactin levels, HOMA score, and BMI. Our data suggest that cabergoline treatment causes an improvement in insulin sensitivity and inflammatory markers and causes a decrease in CIMT independent from the decrease in prolactin, LDL cholesterol, and BMI. We conclude that short term cabergoline treatment can improve endothelial function independently from the changes in metabolic disturbances and inflammatory markers.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Endocrinology

a Topical term or geographic name as entry element Prolactinoma;

a Topical term or geographic name as entry element Carotid intima media;

a Topical term or geographic name as entry element thickness

a Topical term or geographic name as entry element Insulin resistance.

a Topical term or geographic name as entry element Inflammation

a Topical term or geographic name as entry element Secretıng pıtuıtary-adenomas;

a Topical term or geographic name as entry element Bromocrıptıne

g Relationship information Aug 2013, Vol.44, Issue:1, p.193-199

t Title Endocrine

x International Standard Serial Number 1355008X

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s12020-012-9857-y