a Record control number 000257811700013

a ISSN 0931-041X

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WJ300

b Item number .S23 2008

a Personal name Soylu, Alper.

h Medium Electronic Document

a Title Saccharomyces boulardii prevents oral-poliovirus vaccine- induced IgA nephropathy in mice.

c Statement of responsibility, etc Alper Soylu, Sema Berktaş, Sülen Sarıoğlu,Güven Erbil, Osman Yılmaz, Belde K. Demir,Yahya Tufan, Didem Yeşilırmak, Mehmet Türkmen,Salih Kavukçu.

c Date of publication, distribution, etc 2008.

b Name of publisher, distributor, etc Springer,

a Place of publication, distribution, etc New York :

a Summary, etc Immunoglobulin A nephropathy (IgAN) is associated with mucosal IgA defect. Probiotics regulate specific and innate immunity. We evaluated the effect of Saccharomyces boulardii on experimental IgAN in mice. Four groups of BALB/ c mice (eight for each) were formed. Group 1 was immunized by oral poliovirus vaccine (OPV) at 0, 14, and 28 days. Group 2 was also given S. boulardii in addition to OPV. Group 3 was given only S. boulardii, whereas group 4 received no treatment. At week 6, after urine and serum samples were obtained for urinalysis and serum creatinine and IgA measurements, all animals were sacrificed to get their kidneys for histopathological evaluation. Urinalysis and serum creatinine levels were normal in all groups. Serum IgA level was increased only in group 1. Whereas group 1 had mesangial proliferation, histology was normal in the other groups. Predominant IgA deposition was universal in group 1, whereas it was either not present or minimal in other groups. Three mice in group 1 also had C3 deposition, which was absent in other groups. Electron microscopy revealed mesangial proliferation, matrix expansion, focal glomerular basement membrane thickening and electron- dense deposits in group 1 only, whereas the other groups were normal. In conclusion, enteral S. boulardii prevented OPV- induced IgAN in mice.

a Topical term or geographic name as entry element Urology & Nephrology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Pediatrics

a Topical term or geographic name as entry element IgA nephropathy

a Main entry heading Pediatric Nephrology

g Relationship information AUG 2008, Vol 23 Issue 8, p1287-1291

x International Standard Serial Number 0931-041X

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s00467-008-0813-2