The protective effect of apelin against water-immersion and restraint stress-induced gastric damage (Kayıt no. 241347)
[ düz görünüm ]
| 000 -LEADER | |
|---|---|
| fixed length control field | naa a22 7ar4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150427t xxu||||| |||| 00| 0 tu d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1880-6546 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NEU |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 050 04 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QT104 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 573269 |
| Personal name | Izgut-Uysal, V. Nimet. |
| 245 10 - TITLE STATEMENT | |
| Title | The protective effect of apelin against water-immersion and restraint stress-induced gastric damage |
| Statement of responsibility, etc. | V. Nimet Izgut-Uysal, Burcu Gemici, Ilknur Birsen, Nuray Acar, Ismail Ustunel. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Springer Japan KK, |
| Date of publication, distribution, etc. | 2014. |
| Name of publisher, distributor, etc. | Tokyo |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The aim of the present study was to investigate the gastroprotective effect of apelin on water-immersion and restraint stress (WIRS)-induced gastric lesions. Male Wistar rats were divided into four groups: control, WIRS, F13A + WIRS and F13A. APJ receptor antagonist F13A was administered to rats to determine the influence of apelin on stress-induced gastric injury. WIRS administered for 6 h resulted in the development of gastric mucosal lesions accompanied by a significant increase in plasma corticosterone. WIRS increased the concentration of 4-hydroxynonenol (4-HNE) + malondialdehyde (MDA) and the expression of apelin and hypoxia inducible factor-1 alpha (HIF-1 alpha) in gastric mucosa. In addition, WIRS reduced the mucosal blood flow and gastric prostaglandin E-2 (PGE(2)) concentration. Plasma corticosterone, which was increased due to stress, was significantly decreased in the F13A + WIRS group. Gastric lesions and the 4-HNE + MDA concentration were also higher in the F13A + WIRS compared to the WIRS group. We conclude that apelin has a gastroprotective effect against stress-induced lesions possibly by reducing lipid peroxidation in gastric mucosa. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 125213 |
| Topical term or geographic name entry element | Physiology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 572720 |
| Topical term or geographic name entry element | Near East University Article |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 572723 |
| Topical term or geographic name entry element | Yakın Doğu Üniversitesi Makale |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 573270 |
| Topical term or geographic name entry element | Gastric mucosal injury |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 573271 |
| Topical term or geographic name entry element | Apelin |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 573272 |
| Topical term or geographic name entry element | APJ antagonist |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 573273 |
| Topical term or geographic name entry element | Receptor Messenger-RNA |
| 773 ## - HOST ITEM ENTRY | |
| Related parts | JUL 2014, Vol 64 Issue 4, p279-289 |
| International Standard Serial Number | 1880-6546 |
| Title | Journal Of Physiological Sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s12576-014-0317-8 ">http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s12576-014-0317-8 </a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Call number prefix | QT0000104P762014 |
| Koha item type | Online Electronic Document |
| Total checkouts | Full call number | Barcode | Koha item type | Lost status | Damaged status | Not for loan | Withdrawn status | Home library | Current library | Shelving location |
|---|---|---|---|---|---|---|---|---|---|---|
| QT104 .P76 2014 | EOL-159 | Online Electronic Document | NEU Grand Library | NEU Grand Library | Online electronic |