Boynukalin, F. K. <br/><br/>
C-Met expression pattern in uterine leiomyoma 
Parvaiz Ahmad, Munir Öztürk,  Satyawati Sharma, Salih Gücel. 
 -  I r o g Canada, Inc  2014. 
<br/><br/> Aim: Growth factors take place in the formation and growth of uterine leiomyomas (LMs). Transforming growth factor beta (TGF-beta), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), and insulin-like growth factor (IGF) contribute to the pathophysiology of LMs when they bind with a specific membrane receptor and transmit a signal into the cell. Little is known about hepatocyte growth factor (HGF) and its receptor system c-Met in formation and growth of uterine LMs. The aim of this study was to evaluate the c-Met receptor expression on human myometrium and uterine LMs. Materials and Methods: The study was performed on human myometrium and uterine LMs. Expression of c-Met receptor was evaluated by immunohistochemical analysis. Results: Overexpression of c-Met was found in all LM cases and in none of normal myometrium samples c-Met overexpression was seen. Conclusion: HGF and c-Met receptor complex seem to have role in development of uterine LMs. 
<br/><br/><label>ISSN: </label>0390-6663  
<br/><br/><label>Nat. Bib. Agency Control No.: </label>WOS:000343848800003 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Gynecology.<br/>Near East University Article<br/>Yakın Doğu Üniversitesi Makale
<br/><br/><label>LC Class. No.: </label>WP120