TY  - GEN
AU  - Boynukalin, F. K.
TI  - C-Met expression pattern in uterine leiomyoma
SN  - 0390-6663
AV  - WP120 
PY  - 2014///
PB  - I r o g Canada, Inc
KW  - Gynecology
KW  - Near East University Article
KW  - Yakın Doğu Üniversitesi Makale
N2  - Aim: Growth factors take place in the formation and growth of uterine leiomyomas (LMs). Transforming growth factor beta (TGF-beta), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), and insulin-like growth factor (IGF) contribute to the pathophysiology of LMs when they bind with a specific membrane receptor and transmit a signal into the cell. Little is known about hepatocyte growth factor (HGF) and its receptor system c-Met in formation and growth of uterine LMs. The aim of this study was to evaluate the c-Met receptor expression on human myometrium and uterine LMs. Materials and Methods: The study was performed on human myometrium and uterine LMs. Expression of c-Met receptor was evaluated by immunohistochemical analysis. Results: Overexpression of c-Met was found in all LM cases and in none of normal myometrium samples c-Met overexpression was seen. Conclusion: HGF and c-Met receptor complex seem to have role in development of uterine LMs
ER  -