TY  - GEN
AU  - Coda,Alvin B.
TI  - Global transcriptional analysis of psoriatic skin and blood confirms known disease-associated pathways and highlights novel genomic "hot spots" for differentially expressed genes
SN  - 0888-7543
AV  - WR205  
PY  - 2012///
CY  - San Diego
PB  - Academic Press Inc Elsevier Science
KW  - Psoriasis
KW  - Near East University Article
KW  - Yakın Doğu Üniversitesi Makale
KW  - Biotechnology & Applied Microbiology
KW  - Microarrays
KW  - Pathogenesis
N2  - There are major gaps in our knowledge regarding the exact mechanisms and genetic basis of psoriasis. To investigate the pathogenesis of psoriasis, gene expression in 10 skin (5 lesional, 5 nonlesional) and 11 blood (6 psoriatic, 5 nonpsoriatic) samples were examined using Affymetrix HG-U95A microarrays. We detected 535 (425 upregulated, 110 downregulated) DEGs in lesional skin at 1% false discovery rate (FDR). Combining nine microarray studies comparing lesional and nonlesional psoriatic skin, 34.5% of dys-regulated genes were overlapped in multiple studies. We further identified 20 skin and 2 blood associated transcriptional "hot spots" at specified genomic locations. At 5% FDR, 11.8% skin and 10.4% blood DEGs in our study mapped to one of the 12 PSORS loci. DEGs that overlap with PSORS loci may offer prioritized targets for downstream genetic fine mapping studies. Novel DEC "hot spots" may provide new targets for defining susceptibility loci in future studies. (C) 2012 Elsevier Inc. All rights reserved
UR  - http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.ygeno.2012.05.004
ER  -