Includes bibliographical references and index.

Machine generated contents note: I. Historical Perspective -- A Brief History of ARDS, TR. Martin 3 -- II. Strategies for the Treatment of Acute Lung Injury -- Immunomodulating Strategies in Acute Respiratory Distress Syndrome, M-J. Dubois -- and J-L. Vincent 19 -- Mechanical Ventilation for the Acute Respiratory Distress Syndrome (ARDS): -- How Far Do We Need to Reduce Tidal Volume?, L. Brochard 29 -- Reduced Mortality in Acute Lung Injury and the Acute Respiratory Distress Syndrome -- with Lung Protective Ventilation with Small Tidal Volumes, MA. Matthay 35 -- Does Knowledge of the Infectious Agent Make a Difference in the Treatment of -- Nosocomial Infections?, M. Niederman and JP. Wiener-Kronish 43 -- Selecting Measures for Assessing Quality of Life after Intensive Care, CR. Gross -- and CR. Weinert 48 -- Should NO Be Used in the Treatment of Acute Lung Injury? YES, -- GJ. Baltopoulos 55 -- Nitric Oxide Treatment of the Acute Respiratory Distress Syndrome, -- RG. Spragg 65 -- Use of Glucocorticoids in the Treatment of the Acute Respiratory Distress Syndrome, -- P. O'Reilly, G. Fildissis and GJ. Baltopoulos 70 -- The Art and Science of Weaning Patients with Acute Lung Injury from the Ventilator, -- P. McArdle 78 -- Pathogenesis and Prevention of Acute and Chronic Lung Disease in Newborn Infants, -- JM. Davis 86 -- Gene Therapy for Acute Lung Injury, -- P. Factor and JI. Sznajder 93 -- III. Basic Mechanisms of Lung Injury -- Biological Markers of Acute Lung Injury, -- LB. Ware and MA. Matthay 103 -- The Role of Neutrophils in Acute Lung Injury, -- WL. Lee and GP. Downey 113 -- Signal Transduction Pathways in Lung Epithelial Cells, -- DC. Eaton and L. Jain 124 -- Apoptosis and Injury, -- P. Bitterman and C. Wendt 132 -- Transgenic Modeling of Mechanisms of Protection in Acute Lung Injury, -- AB. Waxman, Z. Zhu, CG. Lee and JA. Elias 140 -- Macrophage Migration Inhibitory Factor (MIF) and Acute Lung Injury, J. Baugh -- and SC. Donnelly 151 -- Role of Tyrosine Phosphorylation in Reactive Oxygen Species-Mediated Vascular -- Endothelial Cell Barrier Dysfunction, AL. Zaiman, SM. Dudek, V. Natarajan -- and JGN. Garcia 158 -- Redox Signalling in Human Vascular Cells: Is There an Antioxidant Stress?, -- RE. Bundy, M. Yacoub and N. Marczin 169 -- Ethanol Ingestion, via Glutathione Depletion, Impairs Alveolar Epithelial Function -- and Renders the Lung Susceptible to Acute Injury during Oxidative Stress, -- DM. Guidot, M. Moss and LAS. Brown 174 -- Exhaled Nitric Oxide (NO) in Acute Lung Injury: Measurements and Physiological -- Implications, N. Marczin, T. Kovesi, D. Royston and M. Yacoub 186 -- Immune Status Evaluation in Bronchoalveolar Lavage in Critically Il ICU Patients -- with ALI, P. Myrianthefs, E. Butzouka, K. Venetsanou, M. Kanakaki, -- P. Evagelopoulou, G. Fildissis and GJ. Baltopoulos 197 -- IV. Solute and Solvent Flux Across the Blood-Gas Barrier: -- Basic Mechanisms and Physiological Implications -- Intracellular Signals Regulating Na+,K+-ATPase Traffic: The Protein Kinase C -- Pathway, AM. Bertorello, CF. Mendez and JI. Sznajder 209 -- Regulation by Hypoxia of Sodium Transport Proteins in Alveolar Epithelium, -- C. Clerici 215 -- Aquaporins: Does Gene Expression Translate to Functional Importance in Lung -- Fluid Balance?, MA. Matthay 222 -- Dopamine Effects on Na,K-ATPase Regulation and Alveolar Fluid Reabsorption, -- JI. Sznajder, KM. Ridge and AM. Bertorello 227 -- V. Host Defense Properties of the Lung -- Role of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Pulmonary -- Viral Infections, I. Davis and S. Matalon 237 -- Transgenic Mice in Studies of Host Defense: Basic Principles for Good Science, -- JM. Hickman-Davis, S. Matalon and JR. Lindsey 248 -- Mechanisms of Pseudomonas Aeruginosa-Induced Injury to the Alveolar Epithelium, -- JP. Wiener-Kronish 254 -- VI. Cellular and Physiological Responses in Hypoxia -- New Concepts in the Regulation of Lung Endothelial Cell Nitric Oxide Synthase -- by Hypoxia, ER. Block 263 -- Mechanisms of Nuclear Factor Kappa B (NF-KB) Activation in Response to LPS -- and Hypoxia, NS. Chandel 272 -- Role of Mitochondrial Oxidant Signaling in the Cellular Responses to Hypoxia, -- PT. Schumacker and NS. Chandel 279.