000			naa a22 7ar4500
005			20151109091556.0
008			150427t xxu||||| |||| 00| 0 tu d
001			265994
016			_a000240458000008
022			_a1612-1872
040			_aNEU
041			_aeng
050	0	4	_aQD31.2
100	1		_9573443 _aÇalış, İhsan, _cProf. Dr.
245	1	0	_aAntitrypanosomal cycloartane glycosides from Astragalus baibutensis _cIhsan Calis, Semra Koyunoglu, Akgul Yesilada, Reto Brun, Peter Rueedi, Deniz Tasdemir.
260			_c2006. _bWiley-V C H Verlag Gmbh, _aWeinheim :
520			_aBaibutoside (5), a new cycloartane-type triterpene glycoside, has been isolated from the roots of Astragalus baibutensis along with four known glycosides, acetylastragaloside 1 (1), and astragalosides 1, 11, and IV (2-4, resp.). The structure elucidation of the compounds were achieved by a combination of one- and two-dimensional NMR techniques (DQF-COSY, HSQC, HMBC, and ROESY), and mass spectrometry (ESI-MS), where all the compounds were shown to have cycloastragenol (=(20R,24S)-3 beta,6 alpha,16 beta,25-tetrahydroxy-20,24-epoxy-9,19-cyclolanostane) as aglycone. All compounds were tested for in vitro antiprotozoal activity. Compounds 1-4 displayed notable activity vs. Trypanosoma brucei rhodesiense, with acetylastragaloside 1 (1) being the most potent (IC50 9.5 mu g/ml). Acetylastragaloside I (1) was also lethal to T cruzi (IC50 5.0 mu g/ml), and it is the first cycloartane-type triterpene with remarkable trypanocidal activity against both T brucei rhodesiense and T cruzi. However, it exhibits some cytotoxicity on mammalian cells.
650		0	_9118251 _aChemistry
650		0	_9572720 _aNear East University Article
650		0	_9572723 _aYakın Doğu Üniversitesi Makale
650		0	_9574781 _aBiochemistry & Molecular Biology
650		0	_9574841 _aTriterpene Glycosides
650		0	_9574842 _aLymphocyte-Proliferation
773			_g2006, Vol 3 Issue 8, p923-929 _tChemistry & Biodiversity _x16121872
856			_uhttp://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1002/cbdv.200690094
942			_x1000007 _kQD00000312A582006 _cOED
999			_c242671