000			naa a22 7ar4500
016			_a000281020000004
022			_a00414301
040			_aNEU
041			_aeng
050	0	4	_aWJ 301
100	1		_9576308 _aBesbas, N.
245	1	0	_aClinical course of primary focal segmental glomerulosclerosis (FSGS) in Turkish children: a report from the Turkish Pediatric Nephrology FSGS Study Group. _cNesrin Besbas, Fatih Ozaltin, Sevinc Emre et al.
260			_c2010. _bTurkish J Pediatrics,
520			_aThe clinical course of focal segmental glomerulosclerosis (FSGS) is heterogeneous in children. To evaluate the clinical course and the predictors of outcome in Turkish children with primary FSGS, a retrospective study was conducted by the Turkish Pediatric Nephrology Study Group in 14 pediatric nephrology centers. Two hundred twenty-two patients (92 boys, 130 girls, aged 1-16 years) with biopsy-proven primary FSGS were included. One hundred forty-eight patients were followed-up for a median of 51 months (range: 0.26-270). The clinical course was characterized by complete remission in 50 (33.8%), persistent proteinuria in 50 (33.8%) and progression to renal failure in 48 (32.4%) patients. Progression to end-stage renal disease (ESRD) was significantly higher in patients who did not attain remission. Complete remission, partial remission and progress to renal failure were recorded in 37%, 32% and 28%, respectively, of the patients (n=73) treated with prednisone combined cyclophosphamide/cyclosporine A. However, in patients (n=33) treated with pulse methyl prednisolone plus oral prednisone (up to 20 months) combined with cyclophosphamide, complete remission in 51.5% and partial remission in 27.3% of the patients were noted. Progression to renal failure was observed in 9.1% of this group of patients. Multivariate analysis showed that only plasma creatinine at presentation was an independent predictive value for outcome. Patients with serum creatinine level higher than 1.5 mg/dl had 6.6 times increased rate of progression to renal failure. Failure to achieve remission is a predictor of renal failure in children with primary FSGS. The use of immunosuppressive treatment in conjunction with prolonged steroid seems beneficial in primary FSGS in children.
650		0	_9576309 _aKidney _xDisease
650		0	_9572720 _aNear East University Article
650		0	_9572723 _aYakın Doğu Üniversitesi Makale
650		0	_9118290 _aChildren
773			_aTurkish Journal Of Pediatrics _gMAY-JUN, 2010, 52 3, p255-p261, 7p. _x00414301
942			_x1000007 _kWJ0000301C552010 _cOED
005			20160411133210.0
008			150313t xxu||||| |||| 00| 0 tu d
001			267199
999			_c243866